Maracyn Plus contains two powerful antibiotics, Trimethoprin and Sulfonamide. Biospheres products make use of a revolutionary technology that delivers the antibiotic directly to the fish. Multi-layered microspheres attach to the fish and break down one layer at a time releasing the antibiotics in a controlled regulated manner. A filming agent, Chitosan, which has a molecular structure similar to the natural mucous coat of a fish, seals the treatment in contact with the tissue surface. Maracyn Plus is non-toxic to invertebrates. A slight reduction in biological activity will result from the use of Maracyn Plus. After treatment, carry out a partial water change and add FritzZyme bacteria culture to boost the biological filter. Normal biological activity will resume after Maracyn Plus has been removed from the water. Partial water changes and fresh carbon in the filter are all suitable methods to remove Maracyn Plus from the water.